Europe and Africa to Americas Americas and Europe to Africa
Plants coffee, sugar cane, bananas, melons, olives, barley, wheat, oats, rice, ragweed, bluegrass, dandelions, daisies, clover maize (corn), potatoes, sweet potatoes, peanuts, squash, pumpkins, tomatoes, peppers, papaya, guava, avocado, pineapple, manioc, cacao, chicle, tobacco
Animals cattle, chickens, horses, goats, sheep, pigs llamas, alpacas, turkeys, guinea pigs
Humans African slaves, European merchants, officials, priests, and settlers few
Diseases smallpox, yellow fever, malaria, measles, chicken pox, influenza, common cold syphilis

The categories of humans and diseases indicate what difference between the Americas, Europe, and Africa?
The people of the Americas were least impacted by the Age of Exploration.
The people of the Americas saw a much greater impact on their domestic population than the others.
Native Americans would have had a significant direct impact on Europe and Africa.
Europeans suffered from disease much more than the others did.