In humans, red blood cells lose their nuclei in the process of maturation. The loss of this organelle has several functional consequences. Select all the correct statements below:
A. Removing the nucleus reduces the lifespan of the red blood cell because without DNA, the cell cannot make new proteins.
B. Removing the nucleus increases the surface-to-volume ratio of red blood cells.
C. Removing the nucleus has no impact on the lifespan of the red blood cell.
D. Removing the nucleus enhances the red blood cell's ability to divide and reproduce.
E. The loss of the nucleus in red blood cells results in increased DNA synthesis.