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CB1 agonists such as Tetrahydrocannabinol (THC) reduce calcium influx by blocking the activity of voltage-dependent calcium channels. What effect would this have on the release of glutamate? agonists such as Tetrahydrocannabinol () reduce calcium influx by blocking the activity of voltage-dependent calcium channels. What effect would this have on the release of glutamate? Exocytosis of vesicles containing glutamate from the nerve terminal would increase. Exocytosis of vesicles containing glutamate from the nerve terminal would decrease. There will be no effect.

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Answer:

Exocytosis of vesicles containing glutamate from the nerve terminal would decrease

Explanation:

Glutamate release is regulated by voltage dependent calcium channels. An increase in intracellular Calcium ion concentration is sufficient and necessary to cause glutamate release from astrocytes. Several experiments are done on this study, when these cells are provided with high amount of calcium ions, the glutamate release from nerve terminals increased.

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