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Using the chart, which of the following point mutations will cause the most harmful effect on an individual?




U



C



A



G







UUU

Phenylalanine

UCU

Serine

UAU

Tyrosine

UGU

Cysteine

U

U

UUC

Phenylalanine

UCC

Serine

UAC

Tyrosine

UGC

Cysteine

C



UUA

Leucine

UCA

Serine

UAA

Stop

UGA

Stop

A



UUG

Leucine

UCG

Serine

UAG

Stop

UGG

Tryptophan

G



CUU

Leucine

CCU

Proline

CAU

Hisitidine

CGU

Arginine

U

C

CUC

Leucine

CCC

Proline

CAC

Hisitidine

CGC

Arginine

C



CUA

Leucine

CCA

Proline

CAA

Glutamine

CGA

Arginine

A



CUG

Leucine

CCG

Proline

CAG

Glutamine

CGG

Arginine

G



AUU

Isoleucine

ACU

Threonine

AAU

Asparagine

AGU

Serine

U

A

AUC

Isoleucine

ACC

Threonine

AAC

Asparagine

AGC

Serine

C



AUA

Isoleucine

ACA

Threonine

AAA

Lysine

AGA

Arginine

A



AUG

Methionine/Start

ACG

Threonine

AAG

Lysine

AGG

Arginine

G



GUU

Valine

GCU

Alanine

GAU

Aspartate

GGU

Glycine

U

G

GUC

Valine

GCC

Alanine

GAC

Aspartate

GGC

Glycine

C



GUA

Valine

GCA

Alanine

GAA

Glutamate

GGA

Glycine

A



GUG

Valine

GCG

Alanine

GAG

Glutamate

GGG

Glycine

G

The sequence reads AUU; a change in the second base from U to C
The sequence reads CGA; a change in the first base from C to A
The sequence reads UGU; a change in the third base from U to A
The sequence reads UUA; a change in the first base from U to C and a change in the third base from A to G