Manfred said that the box should not have been unleashed by the enemies which included in it all the evils of the world.
Explanation:
In the box of Pandora, there were all the bad things hid in it. The box of Pandora included the hatred, diseases, poverty, envy and other evil things of the world.
These things were all kept in the box by Zeus which was opened by Pandora and all the evils flew away from the box. But one thing still was trapped in the box and that important thing was hope.
