plz help me this is for a test i’m taking right now.

The normal shape of an enzyme is as shown in structure A. If the enzymes shape changes to that shown in structure B, what are two consequences of this change?

Select all the correct answers.

1. less binding of substrate
2. more binding of substrate
3. won’t follow the lock and key pattern of enzyme binding
4. will follow the lock and key pattern of enzyme binding
5. a substrate reaction independent of the enzyme structure