Examine the data shown in Figures 2 and 3. Carefully compare the DNA methylation profiles from the 3-year-old twins versus the 50-year-old twins and summarize your observations. Which set of twins (3-year-old or 50-year-old) have the most similar DNA methylation profiles? Provide a brief explanation of your observations.
A DNA base is altered biochemically during DNAmethylation, which typically takes place during gametogenesis and after fertilization.
The DNA methyltransferases DNMT1, DNMT3A, and DNMT3B keep methylation marks in tact after each cell division.
Although the majority of methylation marks are stable, there is typically 10% to 20% variation over time. Ly cytosine undergoes enzymatic 5-carbon methylation.
DNA methylation represents the best characterized form of epigenetic modification. DNA methylation is written onto the genome by two methyltransferases, known as Dnmt3a and Dnmt3b.
These enzymes catalyze the addition .
Aging is often marked by the establishment of global hypomethylation and regions of CpG island hypermethylation.
These changes in the epigenetic landscape may contribute to aging by adversely affecting genomic stability and gene regulation.
Thus, DNA methylation has its affect on aging and thus should be observed carefully.
