The Cdc25 molecule's inhibition prevents the cell from entering M phase if DNA is damaged or incompletely duplicated during S phase. The answer is (b).
In mammalian cells, CDC25C is predominately a nuclear protein. It is crucial in the control of cell division. It causes the entry into mitosis by dephosphorylating the Thr14 and Tyr15 residue of cyclinB-bound CDC2. Additionally, it is thought to prevent p53-induced growth arrest. Recent research has shown the dual phosphatase CDC25 as a potential target for a variety of triple-negative breast cancers, including those with RB1/PTEN/P53-deficient tumors.
Additionally, PI3K inhibitors and CDC25 inhibitors work well together to limit the growth of tumors. One of the most important cell cycle regulators is cell division cycle 25 A (Cdc25A), a dual-specificity protein phosphatase that dephosphorylates inhibitory cyclin-dependent kinases (CDKs) like CDK2, CDK4, and CDK6 and positively controls the activities of CDKs that promote cell cycle advancement.
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