Basophil migrates from the blood into the tissues and becomes a mast cell.
One variety of white blood cell is the basophil. The least frequent granulocyte, basophils account for 0.5% to 1% of the circulating white blood cells. They are the biggest form of granulocyte, though. In addition to causing inflammatory reactions during immunological responses, they also have a role in the development of both acute and chronic allergic disorders, such as hay fever, asthma, atopic dermatitis, and anaphylaxis. They also generate substances that help regulate immunological responses, such as heparin, which prevents blood clotting, and substances like histamine and serotonin, which cause inflammation. However, these substances are less abundant than those found in mast cell granules. Mast cells were formerly believed to be basophils that moved from the blood into their native tissues (connective tissue), but they are now understood to be different sorts of cells.
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