ANSWER:-ATP and citrate are both negative regulators of **fructose 1,6-bisphosphatase** (option C). This enzyme is involved in the regulation of gluconeogenesis, which is the process of synthesizing glucose from non-carbohydrate precursors. Both ATP and citrate act as indicators of high energy levels in the cell. When ATP and citrate levels are elevated, it signals that the cell has sufficient energy and does not need to produce more glucose through gluconeogenesis. As a result, fructose 1,6-bisphosphatase is inhibited, reducing the rate of gluconeogenesis.
